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Iron acquisition at the outer membrane (OM) of Gram-negative bacteria is powered by the proton motive force (PMF) of the cytoplasmic membrane (CM), harnessed by the CM-embedded complex of ExbB, ExbD, and TonB. Its stoichiometry, ensemble structural features, and mechanism of action are unkno...

Energy-coupled transport and signal transduction through the gram-negative outer membrane via TonB-ExbB-ExbD-dependent receptor proteins. FEMS Microbiol. Rev. 16, 295–307. doi: 10.1111/j.1574-6976.1995.tb00177.x PubMed Abstract | CrossRef Full Text | Google Scholar Brejda, J. J., Moser,...

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(12), nickel complexes, and carbohydrates. The transport process requires energy in the form of proton motive force and a complex of three inner membrane proteins, TonB-ExbB-ExbD, to transduce this energy to the outer membrane. The siderophore substrates range in complexity from simple small ...

The TonB–ExbB–ExbD molecular motor harnesses the proton motive force across the bacterial inner membrane to couple energy to transporters at the outer membrane, facilitating uptake of essential nutrients such as iron and cobalamine. TonB physically interacts with the nutrient-loaded transporter to ...

The expression of the TonB gene depends on the availability of surrounding iron and the orientation from a specific gene fur, and expressed TonB is associated with ExbBH and ExbD interact to form TonB complexes that act through conformational changes to modulate outer membrane receptors, which ...

K03559exbD; biopolymer transport protein ExbD K03284corA; magnesium transporter K06199crcB; fluoride exporter K03699tlyC; magnesium and cobalt exporter, CNNM family K03286TC.OOP; OmpA-OmpF porin, OOP family K06076fadL; long-chain fatty acid transport protein ...

biopolymer transport protein ExbB K03559 exbD; biopolymer transport protein ExbD K03562 tolQ; biopolymer transport protein TolQ K03560 tolR; biopolymer transport protein TolR K03284 corA; magnesium transporter K06199 crcB; fluoride exporter K03699 tlyC; magnesium and cobalt exporter, CNNM family K03...

Edinburgh Genomics is partly supported through core grants from NERC (R8/H10/56), MRC (MR/ K001744/1) and BBSRC (BB/J004243/1). Author Contributions D.A.S. conceived the study, wrote the main manuscript and prepared the figures with assistance from M.D. and S.B. S.B. performed ...