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(OneDConv), which dynamically transforms the convolution kernels based on the input features in a computationally and parametrically efficient manner. The proposed operator can extract the transform-invariant features naturally. It improves the robustness and generalization of convolution without sacrificing ...

Pevonedistat (TAK-924/MLN4924) is a novel inhibitor of NEDD8-activating enzyme (NAE) with single-agent activity in relapsed/refractory acute myeloid leukemia (AML). We performed a phase 1b study of pevonedistat (PEV) with azacitidine (AZA) based on syner

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML 2018, Blood Citation Excerpt : Two of these patients were successfully rechallenged with lower doses of PEV and remained on protocol. PEV-related hepatic toxicity has been reported in...

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which are critical for proteasome-mediated protein degradation. TNF-αis a cytokine that is involved in inflammatory responses and cell death, among other biological functions. Treatment of cultured cells with the combination of pevonedistat and TNF-α, but not as single agents, resulted in rapid...