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宮路ナオミ[ONED-732]发行于2007-04-19时长118分钟出品商是エスワン ナンバーワンスタイル,ONED-732作品种子搜索下载,宝来みずほ[AWE-004]发行于2007-08-01时长129分钟出品商是AVS collector’s,AWE-004作品种子搜索下载
Nature. 2009 Apr 9;458(7239):732-6. [2]. F S Wolenski, et al. The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis. Cell Death Discovery 1, Article number: 15034 (2015)...
2019/8/136 浏览综合 oned-372-226-941--123-…这是个什么东西??? 更新时间2019/8/13 暴走英雄坛 前往论坛 还没有人转发
MLN4924 对各种人类肿瘤衍生细胞 lines表现出强大的细胞毒性活性。 体内:Pevonedistat (mln4924) (sc、10mg/2 kg、30 mg/2 kg 或 60 mg/2 kg) 抑制 NEDD8 途径, 导致 hct-116 xenografts 小鼠 DNA 损伤。在 scrats中, Pevo...
Pevonedistat (MLN4924)是Nedd8激活酶(NAE)的小分子抑制剂,IC50为4 nM。 CAS: 905579-51-3 规格价格库存购买数量 10mM (1mL in DMSO)RMB 2940.21现货 2mgRMB 876.75现货 5mgRMB 2187.12现货 ...
而当她的番号变为SOE-663, 则表示她由清纯派毕业,投入到一般行列中去了。 再如oned-864时的初音みのり还是S1的自家育成偶像, 活蹦乱跳的小嫩妹一枚。而到了IPZ-074时, 已然成了IDEAPOCKET的受辱他人之妻。 类似的变...
leading to cancer cell death.22In addition to its role in cell cycle machinery, pevonedistat promotes myeloid differentiation of AML cells, leading to antileukemic effects in a xenograft model.23These findings led us to...
Pevonedistat (MLN4924), a selective inhibitor of the NEDD8-activating enzyme E1 regulatory subunit (NAE1), has demonstrated significant therapeutic potential in several malignancies. Although multiple mechanisms-of-action have ...
Pevonedistat (MLN4924)是Nedd8激活酶(NAE)的小分子抑制剂,IC50为4 nM。 特性: MLN4924是NAE抑制剂,并产生一个酶催化的共价的NEDD8-MLN4924加合物。 体外研究: MLN4924在结构上与59-磷酸腺苷(AMP)相关,是NAE反应的紧密结合产物。
2-26, Kyobashicho, Minami-ku, Hiroshima, Hiroshima, Japan, 732-0828 - See map Get your trip off to a great start with a stay at this property, which offers free Wi-Fi in all rooms. Conveniently situated in the...
Antineoplastic Agents Cullin Proteins Cyclopentanes Enzyme Inhibitors NEDD8 Protein NEDD8 protein, human Nedd8 protein, mouse Proteasome Inhibitors Pyrimidines Ubiquitins Ubiquitin-Activating Enzymes pevonedistat ...